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Quantitative Biology > Cell Behavior

arXiv:0806.0856 (q-bio)
[Submitted on 4 Jun 2008 (v1), last revised 6 Jun 2008 (this version, v2)]

Title:New Proposed Mechanism of Actin-Polymerization-Driven Motility

Authors:Kun-Chun Lee, Andrea J. Liu
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Abstract: We present the first numerical simulation of actin-driven propulsion by elastic filaments. Specifically, we use a Brownian dynamics formulation of the dendritic nucleation model of actin-driven propulsion. We show that the model leads to a self-assembled network that exerts forces on a disk and pushes it with an average speed. This simulation approach is the first to observe a speed that varies non-monotonically with the concentration of branching proteins (Arp2/3), capping protein and depolymerization rate (ADF), in accord with experimental observations. Our results suggest a new interpretation of the origin of motility that can be tested readily by experiment.
Comments: 31 pages, 5 figures
Subjects: Cell Behavior (q-bio.CB); Subcellular Processes (q-bio.SC)
Cite as: arXiv:0806.0856 [q-bio.CB]
  (or arXiv:0806.0856v2 [q-bio.CB] for this version)
  https://doi.org/10.48550/arXiv.0806.0856
Related DOI: https://doi.org/10.1529/biophysj.108.134783

Submission history

From: Andrea Liu [view email]
[v1] Wed, 4 Jun 2008 20:32:45 UTC (302 KB)
[v2] Fri, 6 Jun 2008 15:23:39 UTC (302 KB)
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