Mathematics > Dynamical Systems
[Submitted on 14 Feb 2000 (v1), last revised 24 Feb 2001 (this version, v2)]
Title:Structure and Stability of Certain Chemical Networks and Applications to the Kinetic Proofreading Model of T-Cell Receptor Signal Transduction
View PDFAbstract: This paper deals with the theory of structure, stability, robustness, and stabilization for an appealing class of nonlinear systems which arises in the analysis of chemical networks.
The results given here extend, but are also heavily based upon, certain previous work by Feinberg, Horn, and Jackson, of which a self-contained and streamlined exposition is included.
The theoretical conclusions are illustrated through an application to the kinetic proofreading model proposed by McKeithan for T-cell receptor signal transduction. (Update includes, among other topics, remarks on extensions to certain systems with Michaelis-Menten kinetics.)
Submission history
From: Eduardo D. Sontag [view email][v1] Mon, 14 Feb 2000 23:02:12 UTC (140 KB)
[v2] Sat, 24 Feb 2001 15:46:32 UTC (166 KB)
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