Title:Structured psychosocial stress and therapeutic failure

Abstract: Generalized language-of-thought arguments appropriate to interacting cognitive modules permit exploration of how disease states interact with medical treatment. The interpenetrating feedback between treatment and response to it creates a kind of idiotypic hall-of-mirrors generating a synergistic pattern of efficacy, treatment failure, adverse reactions, and patient noncompliance which, from a Rate Distortion perspective, embodies a distorted image of externally-imposed structured psychosocial stress. For the US, accelerating spatial and social diffusion of such stress enmeshes both dominant and subordinate populations in a linked system which will express itself, not only in an increasingly unhealthy society, but in the diffusion of therapeutic failure, including, but not limited to, drug-based treatments.