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Quantitative Biology > Molecular Networks

arXiv:q-bio/0507010 (q-bio)
[Submitted on 7 Jul 2005 (v1), last revised 31 Mar 2006 (this version, v2)]

Title:Integrin activation - the importance of a positive feedback

Authors:Dagmar Iber, Iain D Campbell
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Abstract: Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolved. Here mathematical modeling, with known experimental parameters, is used to show that the binding of a stabilizing factor, such as talin, is alone insufficient to enable ligand-dependent integrin activation for all observed conditions; an additional positive feedback is required.
Comments: in press in Bulletin of Mathematical Biology
Subjects: Molecular Networks (q-bio.MN); Cell Behavior (q-bio.CB); Subcellular Processes (q-bio.SC)
Cite as: arXiv:q-bio/0507010 [q-bio.MN]
  (or arXiv:q-bio/0507010v2 [q-bio.MN] for this version)
  https://doi.org/10.48550/arXiv.q-bio/0507010
Related DOI: https://doi.org/10.1007/s11538-005-9049-5

Submission history

From: Dagmar Iber [view email]
[v1] Thu, 7 Jul 2005 10:36:57 UTC (263 KB)
[v2] Fri, 31 Mar 2006 07:06:13 UTC (822 KB)
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