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Quantitative Biology > Molecular Networks

arXiv:q-bio/0511038 (q-bio)
[Submitted on 23 Nov 2005]

Title:Absolute Rate Theories of Epigenetic Stability

Authors:Aleksandra M. Walczak, José N. Onuchic, Peter G. Wolynes
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Abstract: Spontaneous switching events in most characterized genetic switches are rare, resulting in extremely stable epigenetic properties. We show how simple arguments lead to theories of the rate of such events much like the absolute rate theory of chemical reactions corrected by a transmission factor. Both the probability of the rare cellular states that allow epigenetic escape, and the transmission factor, depend on the rates of DNA binding and unbinding events and on the rates of protein synthesis and degradation. Different mechanisms of escape from the stable attractors occur in the nonadiabatic, weakly adiabatic and strictly adiabatic regimes, characterized by the relative values of those input rates.
Comments: 8 pages, 3 figures
Subjects: Molecular Networks (q-bio.MN)
Cite as: arXiv:q-bio/0511038 [q-bio.MN]
  (or arXiv:q-bio/0511038v1 [q-bio.MN] for this version)
  https://doi.org/10.48550/arXiv.q-bio/0511038
Related DOI: https://doi.org/10.1073/pnas.0509547102

Submission history

From: Aleksandra Walczak [view email]
[v1] Wed, 23 Nov 2005 01:17:20 UTC (899 KB)
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