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Quantitative Biology > Subcellular Processes

arXiv:q-bio/0512027 (q-bio)
[Submitted on 12 Dec 2005 (v1), last revised 3 Sep 2007 (this version, v2)]

Title:A Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes

Authors:Julien Mozziconacci, Christophe Lavelle, Maria Barbi, Annick Lesne, Jean-Marc Victor
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Abstract: During the eukaryotic cell cycle, chromatin undergoes several conformational changes, which are believed to play key roles in gene expression regulation during interphase, and in genome replication and division during mitosis. In this paper, we propose a scenario for chromatin structural reorganization during mitosis, which bridges all the different scales involved in chromatin architecture, from nucleosomes to chromatin loops. We build a model for chromatin, based on available data, taking into account both physical and topological constraints DNA has to deal with. Our results suggest that the mitotic chromosome condensation/decondensation process is induced by a structural change at the level of the nucleosome itself.
Subjects: Subcellular Processes (q-bio.SC)
Cite as: arXiv:q-bio/0512027 [q-bio.SC]
  (or arXiv:q-bio/0512027v2 [q-bio.SC] for this version)
  https://doi.org/10.48550/arXiv.q-bio/0512027
Journal reference: FEBS Letters 580 (2006) 368-372
Related DOI: https://doi.org/10.1016/j.febslet.2005.12.053

Submission history

From: Maria Barbi [view email]
[v1] Mon, 12 Dec 2005 17:05:58 UTC (239 KB)
[v2] Mon, 3 Sep 2007 16:28:22 UTC (239 KB)
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