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Quantitative Biology > Biomolecules

arXiv:q-bio/0511006 (q-bio)
[Submitted on 7 Nov 2005]

Title:Dynamic Pathways for Viral Capsid Assembly

Authors:Michael F. Hagan, David Chandler
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Abstract: We develop a class of models with which we simulate the assembly of particles into T1 capsid-like objects using Newtonian dynamics. By simulating assembly for many different values of system parameters, we vary the forces that drive assembly. For some ranges of parameters, assembly is facile, while for others, assembly is dynamically frustrated by kinetic traps corresponding to malformed or incompletely formed capsids. Our simulations sample many independent trajectories at various capsomer concentrations, allowing for statistically meaningful conclusions. Depending on subunit (i.e., capsomer) geometries, successful assembly proceeds by several mechanisms involving binding of intermediates of various sizes. We discuss the relationship between these mechanisms and experimental evaluations of capsid assembly processes.
Comments: 13 pages, 13 figures. Submitted to Biophys. J
Subjects: Biomolecules (q-bio.BM)
Cite as: arXiv:q-bio/0511006 [q-bio.BM]
  (or arXiv:q-bio/0511006v1 [q-bio.BM] for this version)
  https://doi.org/10.48550/arXiv.q-bio/0511006
Related DOI: https://doi.org/10.1529/biophysj.105.076851

Submission history

From: Michael Hagan [view email]
[v1] Mon, 7 Nov 2005 01:02:50 UTC (455 KB)
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